Enhancing Disease Prediction with a Hybrid CNN-LSTM Framework in EHRs

Authors

  • Jingxiao Tian Electrical and Computer Engineering, San Diego State University, San Diego, US
  • Ao Xiang Digital Media Technology, University of Electronic Science and Technology of China, Chengdu, China
  • Yuan Feng Interdisciplinary Data Science, Duke University, Durham, US
  • Qin Yang Microelectronics Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
  • Houze Liu Computer science, New York University, New York, US

DOI:

https://doi.org/10.53469/jtpes.2024.04(02).02

Keywords:

Deep Learning, Convolutional Neural Network, Long Short Term Memory Neural Network, Hybrid Deep Learning

Abstract

This study developed a novel hybrid deep learning framework aimed at enhancing the accuracy of disease prediction using temporal data from Electronic Health Records (EHRs). The framework integrates Convolutional Neural Networks (CNN) and Long Short-Term Memory (LSTM) networks, leveraging the strength of CNNs in extracting hierarchical feature representations from complex data and the capability of LSTMs in capturing long-term dependencies in temporal information. An empirical investigation on real-world EHR datasets revealed that, compared to Support Vector Machine (SVM) models, standalone CNNs, and LSTMs, this hybrid deep learning network demonstrated significantly higher prediction accuracy in disease prediction tasks. This research not only advances the performance of predictive models in the health data analytics domain but also underscores the importance of adopting and further developing advanced deep learning technologies to address the complexity of modern medical data. Our findings advocate for a shift towards integrating complex neural network architectures in developing predictive models, potentially offering avenues for more personalized and proactive disease management and care, thereby setting new standards for future health management practices.

References

Wei, W.-Q., Teixeira, P.L., Mo, H., Cronin, R.M., Warner, J.L. and Denny, J.C. (2015) Combining Billing Codes, Clini- cal Notes, and Medications from Electronic Health Records Provides Superior Phenotyping Performance. Journal of the American Medical Informatics Association, 23, e20-e27. https://doi.org/10.1093/jamia/ocv130

Henriksson, A., Zhao, J., Bostr?m, H. and Dalianis, H. (2015) Modeling Heterogeneous Clinical Sequence Data in Semantic Space for Adverse Drug Event Detection. IEEE International Conference on Data Science and Advanced Analytics, Paris, 19-21 October 2015, 1-8. https://doi.org/10.1109/DSAA.2015.7344867

Li, L., Yang, Y., Zhan, S., & Wu, B. (2021, May). Sentence dependent-aware network for aspect-category sentiment analysis. In International Conference on Web Engineering (pp. 166-174). Cham: Springer International Publishing.

Hao Xu, Qingsen Wang, Shuang Song, Lizy Kurian John, and Xu Liu. 2019. Can we trust profiling results? Understanding and fixing the inaccuracy in modern profilers. In Proceedings of the ACM International Conference on Supercomputing. 284–295.

Sun, W., Wan, W., Pan, L., Xu, J., & Zeng, Q. (2024). The Integration of Large-Scale Language Models Into Intelligent Adjudication: Justification Rules and Implementation Pathways. Journal of Industrial Engineering and Applied Science, 2(1), 13–20. https://doi.org/10.5281/zenodo.10607564

Yan, X., Xiao, M., Wang, W., Li, Y., & Zhang, F. (2024). A Self-Guided Deep Learning Technique for MRI Image Noise Reduction. Journal of Theory and Practice of Engineering Science, 4(01), 109–117. https://doi.org/10.53469/jtpes.2024.04(01).15

Liu, B., Yu, L., Che, C., Lin, Q., Hu, H., & Zhao, X. (2023). Integration and Performance Analysis of Artificial Intelligence and Computer Vision Based on Deep Learning Algorithms. arXiv preprint arXiv:2312.12872.

Kong, W., Dong, Z.Y., Hill, D.J., Luo, F. and Xu, Y. (2018) Short-Term Residential Load Forecasting Based on Resi- dent Behaviour Learning. IEEE Transactions on Power Systems, 33, 1087-1088. https://doi.org/10.1109/TPWRS.2017.2688178

Funahashi, K.I. and Nakamura, Y. (1993) Approximation of Dynamical Systems by Continuous Time Recurrent Neur- al Networks. Neural Networks, 6, 801-806. https://doi.org/10.1016/S0893-6080(05)80125-X

Krizhevsky, A., Sutskever, I. and Hinton, G.E. (2012) Imagenet Classification with Deep Convolutional Neural Net- works. Proceedings of the 25th International Conference on Neural Information Processing Systems, Lake Tahoe, 3-6 December 2012, 1097-1105.

Weimin WANG, Yufeng LI, Xu YAN, Mingxuan XIAO, & Min GAO. (2024). Enhancing Liver Segmentation: A Deep Learning Approach with EAS Feature Extraction and Multi-Scale Fusion. International Journal of Innovative Research in Computer Science & Technology, 12(1), 26–34. Retrieved from https://ijircst.irpublications.org/index.php/ijircst/article/view/21

Dai, W., Tao, J., Yan, X., Feng, Z., & Chen, J. (2023, November). Addressing Unintended Bias in Toxicity Detection: An LSTM and Attention-Based Approach. In 2023 5th International Conference on Artificial Intelligence and Computer Applications (ICAICA) (pp. 375-379). IEEE.

Yan, K., Du, Y. and Ren, Z. (2018) MPPT Perturbation Optimization of Photovoltaic Power Systems Based on Solar Irradiance Data Classification. IEEE Transactions on Sustainable Energy, 10, 514-521. https://doi.org/10.1109/TSTE.2018.2834415

Ma, D., Dang, B., Li, S., Zang, H., & Dong, X. (2023).

Implementation of computer vision technology based on artificial intelligence for medical image analysis. International Journal of Computer Science and Information Technology, 1(1), 69-76.

Tianbo, S., Weijun, H., Jiangfeng, C., Weijia, L., Quan, Y., & Kun, H. (2023, January). Bio-inspired Swarm Intelligence: a Flocking Project With Group Object Recognition. In 2023 3rd International Conference on Consumer Electronics and Computer Engineering (ICCECE) (pp. 834-837). IEEE.

Hao Xu, Shuang Song, and Ze Mao. 2023. Characterizing the Performance of Emerging Deep Learning, Graph, and High Performance Computing Workloads Under Interference. arXiv:2303.15763

Liu, B. (2023). Based on intelligent advertising recommendation and abnormal advertising monitoring system in the field of machine learning. International Journal of Computer Science and Information Technology, 1(1), 17-23.

Xu, H., & Colmenares, J. A. (2023). Admission Control with Response Time Objectives for Low-latency Online Data Systems. arXiv preprint arXiv:2312.15123.

Hao Xu, Qingsen Wang, Shuang Song, Lizy Kurian John, and Xu Liu. 2019. Can we trust profiling results? Understanding and fixing the inaccuracy in modern profilers. In Proceedings of the ACM International Conference on Supercomputing. 284–295.

Zeiler, M.D. (2012) ADADELTA: An Adaptive Learning Rate Method.

Zang, H., Li, S., Dong, X., Ma, D., & Dang, B. (2024). Evaluating the Social Impact of AI in Manufacturing: A Methodological Framework for Ethical Production. Academic Journal of Sociology and Management, 2(1), 21–25. https://doi.org/10.5281/zenodo.10474511

Wan, W., Xu, J., Zeng, Q., Pan, L., & Sun, W. (2023). Development and Evaluation of Intelligent Medical Decision Support Systems. Academic Journal of Science and Technology, 8(2), 22-25.

Hao Hu, Shulin Li, Jiaxin Huang, Bo Liu, and Chang Che. 2023. Casting Product Image Data for Quality Inspection with Xception and Data Augmentation. Journal of Theory and Practice of Engineering Science 3, 10 (Oct. 2023), 42–46. https: //doi.org/10.53469/jtpes.2023.03(10).06

Ni, F., Zang, H., & Qiao, Y. (2024, January). Smartfix: Leveraging machine learning for proactive equipment maintenance in industry 4.0. In The 2nd International scientific and practical conference “Innovations in education: prospects and challenges of today”(January 16-19, 2024) Sofia, Bulgaria. International Science Group. 2024. 389 p. (p. 313).

Liu, S., Wu, K., Jiang, C., Huang, B., & Ma, D. (2023). Financial Time-Series Forecasting: Towards Synergizing Performance And Interpretability Within a Hybrid Machine Learning Approach. arXiv preprint arXiv:2401.00534.

Sun, W., Wan, W., Pan, L., Xu, J., & Zeng, Q. (2024). The Integration of Large-Scale Language Models Into Intelligent Adjudication: Justification Rules and Implementation Pathways. Journal of Industrial Engineering and Applied Science, 2(1), 13–20. https://doi.org/10.5281/zenodo.10607564

Pan, L., Sun, W., Wan, W., Zeng, Q., & Xu, J. (2023). Research Progress of Diabetic Disease Prediction Model in Deep Learning. Journal of Theory and Practice of Engineering Science, 3(12), 15-21.

Hengyi Zang. (2024). Precision Calibration of Industrial 3D Scanners: An AI-Enhanced Approach for Improved Measurement Accuracy. Global Academic Frontiers, 2(1), 27-37. https://gafj.org/journal/article/view/30

Downloads

Published

2024-02-28

How to Cite

Tian, J., Xiang, A., Feng, Y., Yang, Q., & Liu, H. (2024). Enhancing Disease Prediction with a Hybrid CNN-LSTM Framework in EHRs. Journal of Theory and Practice of Engineering Science, 4(02), 8–14. https://doi.org/10.53469/jtpes.2024.04(02).02